Platelet-rich plasma (PRP), also known as platelet-rich plasma, is a cosmetic procedure based on increasing the concentration of platelets 3-7 times more than the blood, a principle known as the enrichment of platelets. Platelets (blood clots) contain growth factors that are necessary for the differentiation, proliferation, and regeneration of cells in a concentrated form (PDGF, TGF, VEGF, EGF, FGF, IGF-F). Additionally, it secretes a significant number of substances with anti-inflammatory properties (IL1, 4,10,13, IFN) and is effective in tissue damage and wound healing.
It activates collagen in the skin and is effective in skin aging and wrinkles. It is used in hair loss, scars, and aging treatments. It is one of the best-tolerated and most effective treatments applied for hair loss in both men and women. Its efficacy appears to be proven in numerous studies. The application intervals are on average 2-4 weeks, and the treatment lasts 4-8 months depending on the number of sessions. It is a very good option for those who do not benefit from topical minoxidil and other topical-oral treatments. The most successful application in combination with PRP is using it together with minoxidil. PRP and topical minoxidil enhance each other's effects, increasing the release of numerous growth factors, revascularization, and vascularization in the follicles, allowing more oxygen and vitamins to reach the hair follicles.
The effect of the treatment increases in the combination of PRP and dermapen (microneedling). With dermapen, channels are created in the skin with micro-needles, increasing collagen formation, blood circulation in the skin, and the release of growth factors in these areas.
In studies, it has been reported as highly effective, with few side effects and a low rate of recurrence after treatment is discontinued.
In studies on androgenetic alopecia, positive effects were observed in 84% of patients, a significant increase in hair density and number was observed in 50%, and a noticeable increase in hair growth was observed in 34%.
The method of application, technique, number of sessions, and intervals affect the success of the treatment.
It should be performed using a proven method under safe conditions.
The number of growth factors obtained varies according to the application technique, which also affects the results.